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While basal levels of FOXOs expression are beneficial and necessary for the regulation of some hepatic processes, their upregulation is associated with pathological phenotypes and the worst prognosis

Oxidized LDL may stimulate the recruitment of inflammatory white blood cells from the blood to the arterial wall by inducing the expression of vascular cell adhesion molecules

Concomitantly, sulforaphane significantly reduced the nuclear translocation of the pro-inflammatory transcription factor nuclear factor (NF)-B in pancreatic acinar cells, downregulating the expression of NF-B target genes that code for pro-inflammatory mediators, such as tumor necrosis factor- (TNF-), interleukin-1 (IL-1), and IL-6 ( Figure 3 ) (18)

In consequence, Fc receptor targeting was considered in tumor vaccine development